One new fatty acid derivative (3Z,5E)-8-(hydroxymethyl)-2-(3-methoxy-2-methyl-3-oxopropyl)-4,6,10,12-tetramethyltetradeca-2,4-dienoic acid (1) and fifteen known compounds 2-16 were isolated from the Aspergillus sp. SCSIO41324 derived fungus from the deep sea. Comprehensive NMR experiments and high-resolution electrospray ionisation mass spectrometry data were combined to elucidate the structure of this new metabolite. All obtained constituents were evaluated for their bioactivities. Compound 2 showed mild neuraminidase inhibition, with an IC50 value of 74.44 μM. Subsequent molecular docking was performed to explore its binding modes with the enzyme.
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