Summary: Dynamic scientific machine learning (SciML) models that combine mechanistic ordinary differential equations (ODEs) with machine learning (ML) components have applications ranging from learning unknown biological processes to integrating auxiliary data modalities into dynamic modelling. To enable reproducible and efficient SciML training, we introduce PEtab SciML, an interoperable data format for specifying parameter estimation problems in which mechanistic and ML model parameters are jointly estimated from time series data. PEtab SciML supports several ML ODE hybridization patterns in realistic problem setups. It is accompanied by a reference Python library and downstream modelling support in Python/JAX and Julia, provided by AMICI and PEtab.jl, respectively, and a collection of real data benchmarks. Availability and implementation: PEtab SciML is available on GitHub (https://github.com/PEtab-dev/petab_sciml). The reference Python package is installable from PyPI and is continuously tested and supported on Linux, macOS, and Windows.
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