毒害基因组:针对DNA基础模型的后门攻击

Poisoning the Genome: Targeted Backdoor Attacks on DNA Foundation Models

Genomic foundation models trained on DNA sequences have demonstrated remarkable capabilities across diverse biological tasks, from variant effect prediction to genome design. These models are typically trained on massive, publicly sourced genomic datasets comprising trillions of nucleotide tokens, which renders them intrinsically susceptible to errors, artifacts, and adversarial issues embedded in the training data. Unlike natural language, DNA sequences lack the semantic transparency that might