单Cell RNA序列数据截取方法大范围比较分析

A Large-Scale Comparative Analysis of Imputation Methods for Single-Cell RNA Sequencing Data

Single-cell RNA sequencing (scRNA-seq) is inherently affected by sparsity caused by dropout events, in which expressed genes are recorded as zeros due to technical limitations. These artifacts distort gene expression distributions and can compromise downstream analyses. Numerous imputation methods have been proposed to address this, and these methods encompass a wide range of approaches from traditional statistical models to recently developed deep learning (DL)-based methods. However, their com