统一基准框架,用于对46个二进制和连续式多源风险分数工具进行具有执行意识的评价

A harmonized benchmarking framework for implementation-aware evaluation of 46 polygenic risk score tools across binary and continuous phenotypes

Polygenic risk score (PRS) tools differ substantially in statistical assumptions, input requirements, and implementation complexity, making direct comparison difficult. We developed a harmonized, implementation-aware benchmarking framework to evaluate 46 PRS tools across seven binary UK Biobank phenotypes and one continuous trait under three model configurations: null, PRS-only, and PRS plus covariates. The framework integrates standardized preprocessing, tool-specific execution, hyperparameter