ImmSET:基于顺序的 TCR-pMHC 规格的分级

ImmSET: Sequence-Based Predictor of TCR-pMHC Specificity at Scale

T cells are a critical component of the adaptive immune system, playing a role in infectious disease, autoimmunity, and cancer. T cell function is mediated by the T cell receptor (TCR) protein, a highly diverse receptor targeting specific peptides presented by the major histocompatibility complex (pMHCs). Predicting the specificity of TCRs for their cognate pMHCs is central to understanding adaptive immunity and enabling personalized therapies. However, accurate prediction of this protein-protei