This paper introduces \emph{biased mean regression}, estimating the \emph{biased mean}, i.e., $\mathbb{E}[Y] + x$, where $x \in \mathbb{R}$. The approach addresses a fundamental statistical problem that covers numerous applications. For instance, it can be used to estimate factors driving portfolio loss exceeding the expected loss by a specified amount (e.g., $ x=\$10 billion$) or to estimate factors impacting a specific excess release of radiation in the environment, where nuclear safety regula
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