Detection of minimal residual disease (MRD) in cancer patients after surgery can provide an early marker for disease recurrence and guide subsequent treatment decisions. Accurate and sensitive estimat...
Electronic health record (EHR)-linked biobank data facilitate large-scale scientific discoveries such as genome-wide association study (GWAS) on a multitude of phenotypic traits and biomarkers routine...
Genome-scale metabolic models (GEMs) are essential tools for systems biology and rational chassis design, but conventional top-down reconstruction depends heavily on sequence homology and often leaves...
Large Language Models (LLMs) and Vision-Language Models (VLMs) increasingly generate indoor scenes through intermediate structures such as layouts and scene graphs, yet evaluation still relies on LLM ...
The reductive citric acid (rTCA) and reverse oxidative TCA (roTCA) cycles are used by autotrophic Bacteria to fix dissolved inorganic carbon (DIC) at deep-sea and terrestrial hot springs, water treatm...
Iron is one of the most important elements of the Earth, yet its bioavailability is limited in oceanic environments. In this context, deep-sea hydrothermal ecosystems represent one of the major source...
Xylophaga dorsalis is a common Atlantic-Mediterranean mollusc that plays a crucial role in deep-sea habitats, where it digests wood that reaches the seabed through a unique symbiosis with specialised ...
Sea cucumbers, as typical representatives of deep-sea benthic animals, possess significant scientific and economic importance. This investigation examined the genomic structural characteristics and ge...
Bacterial adaptation to fluctuations in salinity includes the intracellular accumulation of organic compounds called compatible solutes (CS) such as the amino acid derivatives ectoine and 5-hydroxyect...
Halisarca dujardinii is a marine sponge known for its ability to completely regenerate via cell reaggregation. Here we present the first chromosome-level genome assembly of H. dujardinii, generated us...
Deep-sea methane seeps host diverse and abundant animal communities, including an extensive undescribed diversity of small cryptic invertebrates. We describe a new genus and species of neomphalid snai...
Carbon fixation in marine ecosystems is a vital process that contributes to climate regulation, with ocean sediments playing a critical role in carbon sequestration. This process is driven by chemolit...
Translational medicine turns underspecified development goals into evidence synthesis that must combine literature, trials, patents, and quantitative multi-omics analysis while preserving identifiers,...
Anaerobic oxidation of methane (AOM) mediated by archaea is a pivotal process for methane consumption in gas seepage-associated sediments. Despite its importance in regulating methane flux, the ecolog...
Dimethylsulfoniopropionate (DMSP) is one of the most important organic sulfur compounds in the ocean and plays a key role in polar carbon and sulfur cycles. Sulfitobacter sp. M13, a Gram-negative and ...
Understanding how molecular alterations propagate across biological systems to drive disease remains a central challenge. Although high-throughput profiling enables comprehensive characterization of t...
High-dimensional biomedical studies require models that are simultaneously accurate, sparse, and interpretable, yet exact best subset selection for generalized linear models is computationally intract...
Azooxanthellate scleractinian corals, which lack symbiotic dinoflagellates, occur from shallow waters to deep-sea environments. In deep-sea benthic ecosystems, they serve as foundation species and are...
The Greenland shark (Somniosus microcephalus) is known for its slow metabolism and deep-sea habitat. It is thought to be the longest-lived vertebrate on Earth, with an estimated lifespan of 392 ± 120 ...
Lindaspio polybranchiata is a deep-sea spionid annelid and an early colonizer of cold seep ecosystems, but genomic resources for this genus remain limited. Here, we present haplotype-resolved chromoso...
