Bacterial cancer therapy exploits anaerobic bacteria's ability to target hypoxia tumor regions, yet the interactions among tumor growth, bacterial colonization, oxygen levels, immunosuppressive cytoki...
How external stimulation is transformed into distributed reaction patterns remains unresolved at the level of propagation architecture. Existing large-scale control models quantify transition costs on...
Alkaptonuria (AKU) is an ultra-rare autosomal recessive metabolic disorder caused by mutations in the HGD (Homogentisate 1,2-Dioxygenase) gene, leading to a pathological accumulation of homogentisic a...
We propose and analyze an optimal control problem associated with a Keller-Segel type parabolic system with chemoattraction, modeling the glioblastoma growth in a bi-dimensional bounded domain, influe...
The proliferation of antibiotic resistance in marine ecosystems represents a critical One Health challenge, particularly within coastal habitats that receive anthropogenic inputs. This study presents ...
The Arctic Ocean plays a pivotal role in global climate, yet its circulation under greenhouse conditions remains poorly constrained. Seismic, sedimentological, and drilling evidence from the Chukchi S...
Global superanoxia is widely accepted as one of the main drivers of the end–Permian Mass Extinction (EPME) alongside, oceanic acidification, productivity collapse, and toxification. However, modeling ...
The northwestern Pacific (NWP) encompasses diverse oceanographic regimes, with the confluence of the warm Kuroshio and the cold Oyashio forming a seasonally shifting ecotone characterized by strong en...
Since the year 2000, oceanic research has seen a surge in data collection, with approximately 500,000 sets of measurements for a single variable (e.g., temperature) recorded annually. Yet, further adv...
Sulfur is a redox active element that may have helped mediate an electron flow that kickstarted life and which presently is an essential element for all life on Earth. Despite current uncertainties in...
The rise of atmospheric oxygen fundamentally transformed Earth's surface environment and enabled the evolution of complex life. However, the processes driving long-term oxygen fluctuations remain poor...
During the Paleocene-Eocene Thermal Maximum (PETM), there was an increase in global temperatures and emissions of isotopically depleted carbon, resulting in a negative carbon isotope excursion (CIE). ...
The 2016 El Niño was the strongest warm-phase of the El Niño-Southern Oscillation recorded to date over the 21st century, leading to the development of severe ocean surface temperature anomalies - mar...
The evolution of El Niño-Southern Oscillation (ENSO) under past and future climate change and its influence on marine ecosystems is highly debated. To examine links between tropical climate variabilit...
The subseafloor biosphere is one of the largest ecosystems on Earth, hosting dense populations of microbial cells. Microbial activity is critical to the Earth's geochemical cycles of major elements su...
Seamount ecosystems are increasingly exposed to rapid oceanographic change, including warming waters, declining oxygen concentrations, and the upward migration of carbonate saturation horizons. Togeth...
Understanding the current and future trajectories of critical habitats is essential for biodiversity conservation and ecosystem management, especially in semi-enclosed environments such as the Mediter...
The southern coast of Europe has been at the center of archaeological debates contrasting the social and cognitive capabilities of Neanderthals and modern humans. Early evidence of marine resource exp...
Oxygen isotope measurements of seawater (δ18Ow) are an important tool in the study of climate, oceanography, and hydrology, both today and in the past. δ18Ow and salinity are controlled by similar hyd...
In recent years, Marine Natural Products (MNPs) have emerged as a significant source for anticancer drug discovery, as many natural products can offer structural diversity, unique mechanisms of action...
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