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Mathematical Modeling of Cancer-Bacterial Therapy: Analysis and Numerical Simulation via Physics-Informed Neural Networks

Bacterial cancer therapy exploits anaerobic bacteria's ability to target hypoxia tumor regions, yet the interactions among tumor growth, bacterial colonization, oxygen levels, immunosuppressive cytoki...

Bayesian covariance regression for differential network analysis of zero-inflated microbiome data

Microbial interaction networks can rewire in response to host and environmental factors, yet most existing methods for network estimation treat the covariance structure as static across samples. We pr...

Non-perturbative Bacterial Identification Directly from Solid Agar Plates Using Raman

Raman spectroscopy is a promising tool for microbial identification, yet its implementation in microbiology and clinical workflow is still restricted due to the accompanying additional preparation req...

Synergistic Impacts of Co-Exposure to Microplastics and Vibrio harveyi on the Immune and Stress Responses of the Big-Belly Seahorse Hippocampus abdominalis.

Microplastics (MPs) originating from synthetic polymers can act as vectors for harmful microorganisms and pollutants, exacerbating ecological risks. Vibrio harveyi, commonly found in seawater, is a ma...

Bioactive pigment production by marine bacteria from Colombian estuarine and deep-sea environments.

Methanotrophic community structure and metabolic potential in the sulfate-methane transition zone of the ARAON mounds, Arctic Chukchi Sea.

Anaerobic oxidation of methane (AOM) mediated by archaea is a pivotal process for methane consumption in gas seepage-associated sediments. Despite its importance in regulating methane flux, the ecolog...

A multidomain lens on the temporal dynamics of surface microbial communities in the Southern Ocean (2013-2019).

Marine microorganisms are vital to biogeochemical cycles and food web dynamics, with their community structure shaped by environmental factors such as temperature, light, and salinity. While microbial...

Molecules, microbes, and function: synchronizing depth-resolved molecular and microbial time series at BATS.

The marine dissolved organic matter (DOM) pool is one of Earth's largest carbon reservoirs and a critical regulator of global carbon flux, yet the microbe-molecule interactions governing it remain lar...

Genomic analysis of Sulfitobacter sp. M13 reveals its role in dimethylsulfoniopropionate (DMSP) metabolism.

Dimethylsulfoniopropionate (DMSP) is one of the most important organic sulfur compounds in the ocean and plays a key role in polar carbon and sulfur cycles. Sulfitobacter sp. M13, a Gram-negative and ...

Water mass specific genes dominate the Southern Ocean microbiome.

The Southern Ocean (SO) plays a key role in regulating global biogeochemical cycles and climate, yet microbial genes sustaining its biological activity remain poorly characterized. We introduce a micr...

TPMM: Three-component Posterior Mixture Model Enables Robust Inverton Detection in Low-Depth Metagenomes and Suggests Potential Viral Invertons

Bacterial phase variation enables reversible, locus-specific phenotypic switching, often driven by DNA inversion (invertons). To identify these events, researchers commonly rely on sequencing reads th...