Detection of minimal residual disease (MRD) in cancer patients after surgery can provide an early marker for disease recurrence and guide subsequent treatment decisions. Accurate and sensitive estimat...
State space models (SSMs) have recently achieved strong performance on long sequence modeling tasks while offering improved memory and computational efficiency compared to transformer based architectu...
Resistance to first-line osimertinib in EGFR-mutant non-small-cell lung cancer (NSCLC) is the canonical example of predictable clonal evolution under therapeutic pressure, yet no public benchmark exis...
In the era of precision medicine, genome-wide epigenetic modifications offer rich data that could inform risk prediction. However, these data are high-dimensional and exhibit complex dependence struct...
Understanding the cellular composition of complex tissues, such as tumors, is a key challenge in biology and medicine. A common approach, known as deconvolution, aims to estimate the cellular composit...
With the rise of checkpoint blockade therapies and neoantigen-based vaccines reaching later-stage trials, there is a growing need for computational tools to identify and prioritize neoantigens. pVACto...
The pretraining data mixture of Large Language Models (LLMs) constitutes their "digital DNA", shaping model behaviors, capabilities, and failure modes. Yet this composition is rarely disclosed, making...
The persistent storage requirements for high-resolution, spatiotemporally evolving fields governed by large-scale and high-dimensional partial differential equations (PDEs) have reached the petabyte-t...
Lonafarnib (LNF) is an investigational drug targeting hepatitis delta virus (HDV) but not hepatitis B virus (HBV), providing a unique opportunity to model HDV kinetics and how changes in HDV affect HB...
Despite their growing importance for contact-free radio frequency (RF) based healthcare monitoring, different radio technologies such as frequency-modulated continuous wave (FMCW) radar, impulse radio...
Force-induced dissociation of short double-stranded DNA (dsDNA) is central to single-molecule biophysics and DNA nanotechnology, yet a physically grounded kinetic description of shear-induced rupture ...
Marine microbiomes play a crucial role in oceanic ecosystems, influencing biogeochemical cycles, climate regulation, and marine biodiversity. Accurate characterization of these microbial communities r...
It is estimated that millions of species exist in the deep-sea environment, such as hydrothermal vents, cold seeps, abyssal plains and seamounts, which have yet to be described. Non-invasive biodivers...
Biomolecular sequence models are increasingly reused outside the studies in which they were introduced, but public checkpoints rarely preserve the execution context needed to inspect source-defined be...
The deep-sea shrimp, Aristeus alcocki Ramadan, 1938, is an economically valuable species belonging to the family Aristeidae under the superfamily Penaeoidea. In this study, we report the complete mito...
The genus Psychromonas includes psychrophilic or psychrotolerant bacteria frequently isolated from cold marine environments, such as polar regions, the deep sea and cold currents, however, its taxonom...
The Greenland shark (Somniosus microcephalus) is a deep-sea vertebrate inhabiting the cold waters of the North Atlantic and Arctic Ocean and is renowned for its exceptional longevity, with individuals...
The Arabian Gulf is a semi-enclosed sea with shallow waters. Its marine fauna must cope with extreme and recurring environmental conditions (high summer temperatures, hypersalinity, hypoxia). In addit...
Hydrothermal systems contain diverse alkanes derived from biological and geological processes, providing potential carbon and energy sources for microorganisms. However, cultivated thermophilic alkane...
A marine hydrocarbonoclastic actinobacterium Kocuria flava IOS11 was isolated from 3500 m deep-sea water of the Indian Ocean. The isolate efficiently degraded phenanthrene (250 mg/L) achieving 82 and ...
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