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Interpretable enzyme function prediction via sparse autoencoder features of ESMC across the microbial protein universe

Microbial genomes and metagenomes contain millions of proteins whose enzymatic functions remain unknown, the enzyme dark matter. While deep learning has improved protein function prediction, most meth...

👤 Yue Hu | Wanyu Cheng | Junqing Wang | Yi... 📰 arXiv 📅 2026 👁 191 📚 9

Advancing the Resolution of the Sulfur Compound Disproportionation Puzzle in Dissulfuribacter Thermophilus S69ᵀ Through Quantitative Label-Free Comparative Proteomics.

In deep-sea hydrothermal vents, sulfur compounds are central for microbial bioenergetics. Despite its significant impact on the global sulfur cycle, anaerobic sulfur compound disproportionation remain...

👤 Fernandez Marilina, Schoepp-Cothenet Bar... 📰 未知期刊 📅 2026 👁 55 📚 9

Sulphur metabolism as a key factor in the evolution of environmental adaptation of Acidihalobacter.

This study compares predicted sulphur metabolism genes across four Acidihalobacter type strains and two metagenome-assembled genomes (MAGs), revealing genomic differences that appear to correspond to ...

👤 Vergara Eva, Khaleque Himel Nahreen, Nei... 📰 Microbial Genomics 📅 2026 👁 44 📚 8

Genome mining reveals an architecturally expanded pyoluteorin-associated biosynthetic gene cluster and a divergent flavin-dependent halogenase-like sequence in deep-sea Pseudomonas Aeruginosa from the Gulf of Guinea.

Marine deep-sea environments harbour microorganisms with extraordinary biosynthetic potential, yet their secondary metabolite repertoires remain largely uncharacterised. This study reports the isolati...

👤 Akinde Sunday Babatunde, Fajoyegbe Emman... 📰 未知期刊 📅 2026 👁 32 📚 1

Genomic analysis of Desulfobulbaceae strain B35, a new hydrothermal vent species of mesophilic bacterium that disproportionates sulfur and respires Fe(III).

Desulfobulbaceae sp. nov. strain B35 is a novel mesophilic, anaerobic, chemolithoautotrophic bacterium isolated from the Lucky Strike deep-sea hydrothermal vent on the Mid-Atlantic Ridge, growing auto...

👤 Hemon Marie, Novák Lukáš V F, Allioux Ma... 📰 未知期刊 📅 2026 👁 25 📚 1
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