Bacterial cancer therapy exploits anaerobic bacteria's ability to target hypoxia tumor regions, yet the interactions among tumor growth, bacterial colonization, oxygen levels, immunosuppressive cytoki...
How external stimulation is transformed into distributed reaction patterns remains unresolved at the level of propagation architecture. Existing large-scale control models quantify transition costs on...
Alkaptonuria (AKU) is an ultra-rare autosomal recessive metabolic disorder caused by mutations in the HGD (Homogentisate 1,2-Dioxygenase) gene, leading to a pathological accumulation of homogentisic a...
We propose and analyze an optimal control problem associated with a Keller-Segel type parabolic system with chemoattraction, modeling the glioblastoma growth in a bi-dimensional bounded domain, influe...
The proliferation of antibiotic resistance in marine ecosystems represents a critical One Health challenge, particularly within coastal habitats that receive anthropogenic inputs. This study presents ...
A systematic chemical investigation of the deep-sea-derived fungus Penicillium limosum ZEN48 resulted in the isolation of four new indole-diketopiperazine alkaloids, limopiperazines A-D (1-4), alongsi...
Background: The mechanisms underlying central nervous system oxygen toxicity (CNS-OT), which manifests as generalized seizures, remain poorly understood, thereby limiting the utility of hyperbaric oxy...
The Arctic Ocean plays a pivotal role in global climate, yet its circulation under greenhouse conditions remains poorly constrained. Seismic, sedimentological, and drilling evidence from the Chukchi S...
Global superanoxia is widely accepted as one of the main drivers of the end–Permian Mass Extinction (EPME) alongside, oceanic acidification, productivity collapse, and toxification. However, modeling ...
Trace elements are a persistent threat to Mediterranean coastal ecosystems, where anthropogenic pressures continue to increase. Although biomarker-based approaches are widely used in marine biomonitor...
Ocean iron fertilization (OIF) is being discussed as a potential carbon dioxide removal (CDR) strategy1. Yet the trade-offs between climate benefits and ecological costs remain poorly understood2-4. H...
Aspertetranones are a unique class of marine fungal meroditerpenoids characterized by a highly oxygenated, linear 6/6/6/6 tetracyclic core fused to an α-pyrone scaffold. Although the pathway of aspert...
Oxygen levels in the ocean have decreased worldwide as a result of climate change and nutrient contamination, which has had a significant impact on marine ecosystems. Although deep-sea fish that resid...
Following the ubiquitous autotrophic ammonia-oxidizing archaea (AOA), heterotrophic representatives of the marine Nitrososphaerota (HMN) form the second most abundant group within this archaeal phylum...
Fungal polyisoprenylated benzophenones typically exhibit potent biological activities. In our previous research, a series of novel polyisoprenylated benzophenones, namely lithocarols A-F, were discove...
The northwestern Pacific (NWP) encompasses diverse oceanographic regimes, with the confluence of the warm Kuroshio and the cold Oyashio forming a seasonally shifting ecotone characterized by strong en...
Olympic Coast National Marine Sanctuary (OCNMS) off Washington State was designated by the National Oceanic and Atmospheric Administration (NOAA) in 1994 and is embedded in the northern California Cur...
Since the year 2000, oceanic research has seen a surge in data collection, with approximately 500,000 sets of measurements for a single variable (e.g., temperature) recorded annually. Yet, further adv...
Sulfur is a redox active element that may have helped mediate an electron flow that kickstarted life and which presently is an essential element for all life on Earth. Despite current uncertainties in...
The rise of atmospheric oxygen fundamentally transformed Earth's surface environment and enabled the evolution of complex life. However, the processes driving long-term oxygen fluctuations remain poor...
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