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MetaGEM: Bottom-Up Reconstruction of Genome-Scale Metabolic Networks via Deep Enzyme-Metabolite Anchoring

Genome-scale metabolic models (GEMs) are essential tools for systems biology and rational chassis design, but conventional top-down reconstruction depends heavily on sequence homology and often leaves...

👤 Weiyu Xiao | Jiangbin Zheng | Stan Z. Li 📰 arXiv 📅 2026 👁 82 📚 26

Causal Inference with Multiple Misclassified Exposures: A Control Variate-Adjusted Calibration Weighting Approach

Exposure misclassification is a common concern in studies of respiratory infections in cystic fibrosis. Throat swabs are frequently used in place of expectorated or induced sputum cultures, although t...

👤 Nandini Murali | Keith Barnatchez | Jord... 📰 arXiv 📅 2026 👁 124 📚 23

Isolation and Characterization of Glycosylated Fatty Acid Amides from the Norwegian Deep-Sea Sponge Phakellia sp.

Marine organisms from deep-sea environments have attracted considerable attention in drug discovery because they produce structurally diverse natural products. However, Norwegian deep-sea ecosystems r...

👤 Vinh Le Ba, Petersen Sindre Wesley, Rodr... 📰 未知期刊 📅 2026 👁 58 📚 10

Bioinspired Antimicrobial Strategy: An Extremophile Deep Sea Peptide to Combat Cystic Fibrosis Infections Caused by Pseudomonas aeruginosa and Staphylococcus aureus.

Cystic fibrosis (CF)-associated lung infections caused by Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus) remain difficult to treat due to multidrug resistance and the red...

👤 Boidin-Wichlacz Céline, Maresca Marc, Gr... 📰 Marine Drugs 📅 2026 👁 30 📚 5

Genome mining reveals an architecturally expanded pyoluteorin-associated biosynthetic gene cluster and a divergent flavin-dependent halogenase-like sequence in deep-sea Pseudomonas Aeruginosa from the Gulf of Guinea.

Marine deep-sea environments harbour microorganisms with extraordinary biosynthetic potential, yet their secondary metabolite repertoires remain largely uncharacterised. This study reports the isolati...

👤 Akinde Sunday Babatunde, Fajoyegbe Emman... 📰 未知期刊 📅 2026 👁 32 📚 1
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