Exercise Attenuates Aortic Dissection Via PDE5A-Mediated Inhibition of Vascular Smooth Muscle Cell Phenotypic Switch
Yi Zhang (Third Affiliated Hospital of Sun Yat-sen University/中国), Chunyan Wu (The First Affiliated Hospital of Guangzhou Medical University/中国), Dongdong Du (The Second Affiliated Hospital of Nanchang University/中国), Jiayi Hu (University of Iowa/美国), Zhiqing Li (The University of Iowa/美国) 等12人
📖 Arteriosclerosis, Thrombosis, and Vascular Biology
📅 2026-03-19
aortic dissection
vascular smooth muscle cell
phenotypic switch
PDE5A
RUNX1
exercise
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Targeting Endothelial PDK4-EndoMT Feedback Loop Mitigates the Development of Thoracic Aortic Dissection in Mice
Xiangyu Cao (Kumamoto University/日本), Xingyou Guo (Tokai University/日本), Haoyue Huang (Juntendo University/日本), Han Shen (University of Tokyo/日本), Jingze Zhu 等14人
📖 Arteriosclerosis, Thrombosis, and Vascular Biology
📅 2026-03-19
thoracic aortic dissection
endothelial-to-mesenchymal transition
PDK4
SNAI1
vascular integrity
dichloroacetate
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